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Dimethylamine → 4-(3,5-dichloropyridin-4-ylamino)-8-(8-(dimethylamino)octyloxy)-7-methoxy-2H-chromen-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylamine | HCID 674 | — |
| 反応物 | 1,8-Dibromooctane | HCID 78310 | — |
| 反応物 | 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one | HCID 24849570 | — |
| 生成物 | 4-(3,5-dichloropyridin-4-ylamino)-8-(8-(dimethylamino)octyloxy)-7-methoxy-2H-chromen-2-one | HCID 24849257 | — |
反応手順
The title compound was prepared from dimethylamine, 1,8-dibromooctane, and 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one (Example 29) following the procedures outlined in Examples 25 & 27. 1H NMR (400 MHz, DMSO-d6): δ 9.38 (br s, 1H), 8.59 (s, 2H), 7.85 (d, 1H), 7.05 (d, 1H), 4.26 (br s, 1H), 3.95 (t, 2H), 3.87 (s, 3H), 2.50 (br, 2H), 2.34 (s, 6H), 1.67 (m, 2H), 1.45 (m, 4H), 1.28 (m, 6H); MS (ESI): 508.0.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745646B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-6462af9a9767446f9b6606d00ceb63be |
| 出典メモ | uspto-grants-2010_06 |