関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylamine | HCID 674 | — |
| 反応物 | 6-Fluoroisoquinolin-1(2H)-one | HCID 45090802 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 6-(Dimethylamino)-1,2-dihydroisoquinolin-1-one | HCID 57424142 | — |
反応手順
6-Fluoro-2H-isoquinolin-1-one (54 mg, 0.33 mmol) was deposited in a sealed tube with 5 mL 33% dimethylamine in ethanol. This was heated at 150° C. for 3.5 hours. This was concentrated in vacuo and purified by flash chromatography (gradient elution 50 to 100% ethyl acetate/hexanes) to yield 6-Dimethylamino-2H-isoquinolin-1-one (39 mg, 0.21 mmol). MS (ESI) 189.1 (M+H)−.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08299077B2 |
|---|
| 出典データセット | uspto-grants-2012_10 |
|---|
| ORD ID | ord-45bdd3b449d544b8801d551331c06025 |
|---|
| 出典メモ | uspto-grants-2012_10 |
|---|
