Dichloromethane → Valine methyl ester
反応式
Cl.[NH2:2][C@H:3]([C:7]([OH:9])=[O:8])[CH:4]([CH3:6])[CH3:5].Cl[CH2:11]Cl>>[CH3:11][O:8][C:7](=[O:9])[C@H:3]([CH:4]([CH3:6])[CH3:5])[NH2:2]参加物
3
実験手順
500 mg of methyl ester of L-(+)-valine hydrochloride are placed in a round-bottom flask. 45 mL of buffer solution (K2HPO4/K3PO4 (pH=12.4)), then 22.5 mL of anhydrous dichloromethane are successively added. The mixture is agitated at room temperature for 30 min. The organic phase is separated, washed with brine, dried on magnesium sulfate, filtered and concentrated under vacuum.
後処理
- customThe organic phase is separated
- washwashed with brine
- customdried on magnesium sulfate
- filtrationfiltered
- concentrationconcentrated under vacuum
出典と根拠
- ORDレコード
- ord-21885dc629d74c55b99e3a5e8f9ffdb8
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08299250B2
反応ノート
読み込み中…