Acetic Acid → 6-(4-Chlorophenyl)-2,3-dihydropyridazin-3-one

HRID 2070

反応式

HRID 2070 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:9][CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1.C(O)(=O)C.BrBr>O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 176Acetic AcidHCID 24408BromineHCID 1209906-(4-Chlorophenyl)-4,5-Dihydropyridazin-3(2H)-One

生成物 1

HCID 6890856-(4-Chlorophenyl)-2,3-dihydropyridazin-3-one収率 93.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of 6-(4-chlorophenyl)-4,5-dihydropyridazinone (11.75 g) and glacial acetic acid (100 ml) was added dropwise 3 ml of bromine and the mixture was heated at 60°-70° C. for 3 h. The resulting mixture was cooled and slowly poured into 400 ml of cold water. The resulting white solid was filtered and dried to yield 10.83 g (89%) of 6-(4-chlorophenyl)pyridazinone.

後処理

  1. temperaturethe mixture was heated at 60°-70° C. for 3 h
  2. temperatureThe resulting mixture was cooled
  3. filtrationThe resulting white solid was filtered
  4. customdried

出典と根拠

ORDレコード
ord-5f7f1d1943894178b387870f0ce435aa
出典データセット
uspto-grants-1998_03
特許番号
US05728694

関連ノート

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