HCID 59398554、化合物 → HCID 59398530、化合物
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]#[C:11][CH2:12][CH2:13][OH:14])=[C:6]([C:15]([F:18])([F:17])[F:16])[CH:5]=1)([O-])=O>CO.[C].[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][CH2:12][CH2:13][OH:14])=[C:6]([C:15]([F:16])([F:17])[F:18])[CH:5]=1参加物
4
実験手順
4-(4-Nitro-2-(trifluoromethyl)phenyl)but-3-yn-1-ol (156 mg, 0.60 mmol) was dissolved in methanol (2 mL), and palladium carbon (10%, 30 mg) was added thereto. The resulting mixture was stirred under hydrogen atmosphere at room temperature for 4 hours. The catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure to give 4-(4-amino-2-(trifluoromethyl)phenyl)butan-1-ol (220 mg, quantitative) as a yellow oil.
後処理
- customThe catalyst was removed by filtration
- concentrationthe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-e6b1ef4bdc3245a1ac2ce77009859f91
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08299252B2
反応ノート
読み込み中…