関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Cyclohexylphenol | HCID 14327 | — |
| 反応物 | 1-Chloro-2,5-dimethyl-4-nitrobenzene | HCID 252793 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-(4-Cyclohexylphenoxy)-2,5-dimethylnitrobenzene | HCID 68596208 | 88.9% |
反応手順
5.81 g (33.0 mmol) of 4-cyclohexylphenol, 5.57 g (30.0 mmol) of 4-chloro-2,5-dimethyl-nitrobenzene and 6.22 g (45.0 mmol) of potassium carbonate are suspended in 30 ml of N,N-dimethylformamide and the suspension is stirred at 150° C. for 12 h. It is then poured into ice-water and the precipitate is isolated by filtration, washed repeatedly with hexane and dried under reduced pressure (12.1 g, purity 71.9%, yield 88.9%, log P (pH 2.3)=6.69).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08299302B2 |
|---|
| 出典データセット | uspto-grants-2012_10 |
|---|
| ORD ID | ord-199e4806684a4b0891602834b97497ad |
|---|
| 出典メモ | uspto-grants-2012_10 |
|---|
