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HRID 2070288作成日：2026年10月27日
Methyl iodide → 4-({2-[(4-bromophenyl)amino]-1-methyl-1H-1,3-benzodiazol-6-yl}oxy)-N-methylpyridine-2-carboxamide
https://huagongshe.com/reaction/2070288
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | 4-Bromophenyl isothiocyanate | HCID 16133 | — |
| 反応物 | {4-[4-Amino-3-(methylamino)phenoxy](2-pyridyl)}-n-methylcarboxamide | HCID 58385469 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-({2-[(4-bromophenyl)amino]-1-methyl-1H-1,3-benzodiazol-6-yl}oxy)-N-methylpyridine-2-carboxamide | HCID 22040978 | — |
反応手順
A solution of the {4-[4-amino-3-(methylamino)phenoxy](2-pyridyl)}-N-methylcarboxamide (1 eq) in methanol was treated with 4-bromophenylisothiocyanate (1 eq) and stirred at 60° C. for 2 hours. The reaction mixture was cooled down to room temperature and iodomethane (1 eq) was added and stirred overnight at 60° C. The reaction was concentrated and preparative chromatography gave (4-{2-[(4-bromophenyl)amino]-1-methylbenzimidazol-6-yloxy)-(2-pyridyl)-N-methylcarboxamide. MS: MH+=452.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08299108B2 |
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| 出典データセット | uspto-grants-2012_10 |
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| ORD ID | ord-6ddbcf52b2e1440b9b19a2490d919581 |
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| 出典メモ | uspto-grants-2012_10 |
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