Benzyl Bromide → alpha,alpha-Dimethyl-2-(phenylmethoxy)-benzeneacetamide

HRID 2070748ノート

反応式

HRID 2070748 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([CH3:13])([CH3:12])[C:9]([NH2:11])=[O:10].C(=O)([O-])[O-].[K+].[K+].[CH2:20](Br)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>CN(C=O)C.O>[CH3:12][C:8]([CH3:13])([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[O:1][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:9]([NH2:11])=[O:10]

参加物

6

反応物 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 866632482-Hydroxy-alpha,alpha-dimethyl-benzeneacetamide

生成物 1

HCID 66689021alpha,alpha-Dimethyl-2-(phenylmethoxy)-benzeneacetamide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
25 °C

実験手順

A solution of 2-hydroxy-α,α-dimethyl-benzeneacetamide (Example 198b, 15.34 g) dissolved in DMF (150 mL) was treated with potassium carbonate (11.83 g) and benzyl bromide (10.18 mL) under nitrogen. The resulting mixture was stirred at 25° C. for 16 h. The reaction mixture was diluted with water (500 mL) and stirred for 30 min. The solid was filtered off and washed with water and dried in vacuo to afford the subtitle compound (19.45 g).

後処理

  1. stirringstirred for 30 min
  2. filtrationThe solid was filtered off
  3. washwashed with water
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-137c258644c749679477545e8ee13f48
出典データセット
uspto-grants-2012_10
特許番号
US08299246B2

反応ノート

読み込み中…