4-Methoxypyrimidine-2-carbonitrile → (4-Methoxypyrimidin-2-yl)methanamine

HRID 2070969ノート

反応式

HRID 2070969 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]#[N:10])[N:4]=1>CO.[OH-].[NH4+].[Ni]>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([CH2:9][NH2:10])[N:4]=1

参加物

5

反応物 1

HCID 132211894-Methoxypyrimidine-2-carbonitrile

生成物 1

HCID 59569974(4-Methoxypyrimidin-2-yl)methanamine

試薬・触媒・溶媒 3

HCID 935Nickel触媒HCID 887Methanol溶媒HCID 14923Ammonium Hydroxide溶媒

実験手順

To 4-methoxypyrimidine-2-carbonitrile (370 mg) in MeOH (5 mL), aqueous ammonium hydroxide (1 mL) and Raney Nickel (catalytic) were added and the reaction mixture was hydrogenated at 55 psi for 2 h. Then the reaction mixture was filtered and solvent evaporated to afford (4-methoxypyrimidin-2-yl)methanamine, which was carried to next step without purification.

後処理

  1. filtrationThen the reaction mixture was filtered
  2. customsolvent evaporated

出典と根拠

ORDレコード
ord-96dbed3f826a40d8ae33ac82dd32bb24
出典データセット
uspto-grants-2012_10
特許番号
US08299267B2

反応ノート

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