Hydrochloric Acid → 3-(1,1-Difluoroethyl)benzonitrile

3-(1,1-difluoroethyl)benzonitrile was synthesized from 3-acetylbenzonitrile following the method described for 3-bromo-5-(1,1-difluoroethyl)pyridine. A solution of 3-(1,1-difluoroethyl)benzonitrile (1.6 g, 9.57 mmol) in CH2Cl2 (25 mL) was cooled to 0° C. and was treated dropwise with a 1 M solution of DIBAL in hexanes (11.5 mL, 11.2 mmol). The mixture was allowed to slowly warm to room temperature. The reaction was monitored by TLC. After 3 h, the reaction mixture was poured into a beaker containing crushed ice and 6 N HCl. The mixture was stirred for about 1 h. The layers were separated and the aqueous phase was extracted with CH2Cl2. The combined organic layer was washed with aqueous NaHCO3 followed by water. The organic layer was dried (Na2SO4), concentrated, and silica chromatographed to afford 3-(1,1-difluoroethyl)benzaldehyde as a light yellow oil, which was used directly for next step without further purification and identification.

1. additionthe reaction mixture was poured into a beaker
2. additioncontaining
3. customThe layers were separated
4. extractionthe aqueous phase was extracted with CH2Cl2
5. washThe combined organic layer was washed with aqueous NaHCO3
6. dry with materialThe organic layer was dried (Na2SO4)
7. concentrationconcentrated
8. customsilica chromatographed

ORDレコード

ord-15c4507bb473494d82639f279e455614

出典データセット

uspto-grants-2012_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08299267B2