Hydrochloric Acid → 3-(Methoxycarbonyl)-4-methylbenzoic acid
反応式
[CH:1]([C:3]1[CH:4]=[CH:5][C:6]([CH3:13])=[C:7]([CH:12]=1)[C:8]([O:10][CH3:11])=[O:9])=[O:2].[OH:14]OS([O-])=O.[K+].O.Cl>CN(C=O)C.CCOC(C)=O>[CH3:11][O:10][C:8]([C:7]1[CH:12]=[C:3]([CH:4]=[CH:5][C:6]=1[CH3:13])[C:1]([OH:14])=[O:2])=[O:9]参加物
7
実験手順
A mixture of 268 mg of the methyl 5-formyl-2-methylbenzoate and 1.08 g (1.76 mmol) of Oxone in 6 mL of DMF was stirred at r.t. for 16.75 h. Water, 1N HCl, and EtOAc were added, and the aqueous layer was extracted with EtOAc. The combined extracts were dried over Na2SO4, filtered, and concentrated, and 3-(methoxycarbonyl)-4-methylbenzoic acid, which was used for the next reaction without further purification.
後処理
- extractionthe aqueous layer was extracted with EtOAc
- dry with materialThe combined extracts were dried over Na2SO4
- filtrationfiltered
- concentrationconcentrated
- custom3-(methoxycarbonyl)-4-methylbenzoic acid, which was used for the next reaction without further purification
出典と根拠
- ORDレコード
- ord-430dedf4208244fc83ed6b0850c8dd3a
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08299267B2
反応ノート
読み込み中…