Benzene → 2-[1-Chloromethyl-3-(5-bromothiazol-2-yl)ureido]acetaldehyde

HRID 2071268ノート

反応式

HRID 2071268 の反応式
[Br:1][C:2]1[S:6][C:5]([N:7]=[C:8]=[O:9])=[N:4][CH:3]=1.C1C=CC=CC=1.[Cl:16][CH2:17][NH:18][CH2:19][CH:20]=[O:21]>C(O)C.O>[Cl:16][CH2:17][N:18]([CH2:19][CH:20]=[O:21])[C:8]([NH:7][C:5]1[S:6][C:2]([Br:1])=[CH:3][N:4]=1)=[O:9]

参加物

5

反応物 3

HCID 241BenzeneHCID 203927162-ChloromethylaminoacetaldehydeHCID 230622645-Bromothiazol-2-yl Isocyanate

生成物 1

HCID 227684992-[1-Chloromethyl-3-(5-bromothiazol-2-yl)ureido]acetaldehyde

試薬・触媒・溶媒 1

HCID 19096565Water ethanol溶媒

実験手順

5-Bromothiazol-2-yl isocyanate dimer (17.0 grams), benzene (70 ml) and the dimethyl acetal of 2-chloromethylaminoacetaldehyde (13.5 grams) are charged into a glass reaction vessel equipped with a mechanical stirrer and thermometer. The reaction mixture is then stirred at room temperature for a period of about one hour. After this time the reaction mixture is filtered, and the filtrate is stripped of solvent under reduced pressure, leaving an oil. This oil is dissolved in an ethanol-water mixture, and the solution is filtered. The filtrate is then stripped of solvents under vacuum to yield the desired product the dimethyl acetal of 2-[1-chloromethyl-3-(5-bromothiazol-2-yl)ureido]acetaldehyde.

後処理

  1. customequipped with a mechanical stirrer
  2. filtrationAfter this time the reaction mixture is filtered
  3. customleaving an oil
  4. filtrationthe solution is filtered

出典と根拠

ORDレコード
ord-7efefc14b16a4ad79290f8dbfab67bd4
出典データセット
uspto-grants-1977_09
特許番号
US04046768

反応ノート

読み込み中…