Sulfuric Acid → HCID 178513793、化合物

HRID 2071308

反応式

HRID 2071308 の反応式
[C:1]1([C:7]2[N:12]=[C:11]([OH:13])[CH:10]=[N:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(=O)(=O)(O)O.C1(C2N=C[C:28]([OH:31])=[N:29]C=2)C=CC=CC=1.ClC1C=NC=C(C2C=CC=CC=2)N=1.ClC1C=NC(C2C=CC=CC=2)=CN=1.CC(C1C=NC=C(C2C=CC=CC=2)N=1)(C(OCC)=O)C(OCC)=O.CC(C1C=NC(C2C=CC=CC=2)=CN=1)(C(OCC)=O)C(OCC)=O.CC(C1C=NC=C(C2C=CC=CC=2)N=1)C(OCC)=O.CC(C1C=NC(C2C=CC=CC=2)=CN=1)C(OCC)=O.CC(C1C=NC=C(C2C=CC=CC=2)N=1)C(O)=O.CC(C1C=NC=C(C2C=CC=CC=2)N=1)C(N)=O>>[OH:13][C:11]1[C:10]([C:28]([NH2:29])=[O:31])=[N:9][CH:8]=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:12]=1

参加物

12

反応物 11

HCID 1118Sulfuric AcidHCID 12366642-Chloro-5-phenylpyrazineHCID 52160922-Chloro-6-phenylpyrazine2 回HCID 21413159alpha-Methyl-6-phenylpyrazineacetic acidHCID 21413165Ethyl alpha-methyl-5-phenylpyrazineacetate2 回HCID 21413174Ethyl alpha-methyl-6-phenylpyrazineacetate3 回HCID 21413182alpha-Methyl-6-phenylpyrazineacetamideHCID 21413214Diethyl alpha-methyl-6-phenylpyrazinylmalonate2 回HCID 21413242Diethyl alpha-methyl-5-phenylpyrazinylmalonateHCID 178516747HCID 178516747、化合物HCID 178516765HCID 178516765、化合物2 回

生成物 1

HCID 178513793HCID 178513793、化合物

実験手順

3-Hydroxy-5-phenylpyrazine-2-carboxamide is prepared by the method of Dick, Wood and Logan, J. Chem. Soc., 2131 (1956). The carboxamide is converted to 6-phenylpyrazinol by the method of Jezo and Luzak, Chem. Zvest., 22, 190 (1968), using 80 percent sulfuric acid at 180° C. Using the procedure of Example III and replacing 5-phenylpyrazinol with an equivalent amount of 6-phenylpyrazinol, the product obtained is 2-chloro-6-phenylpyrazine. Using the procedure of Example V and replacing 2-chloro-5-phenylpyrazine with an equivalent amount of 2-chloro-6-phenylpyrazine, the product obtained is diethyl α-methyl-6-phenylpyrazinylmalonate. Using the procedure of Example VI and replacing diethyl α-methyl-5-phenylpyrazinylmalonate with an equivalent amount of diethyl α-methyl-6-phenylpyrazinylmalonate, the product obtained is ethyl α-methyl-6-phenylpyrazineacetate. Using the procedure of Example IX and replacing ethyl α-methyl-5-phenylpyrazineacetate with an equivalent amount of ethyl α-methyl-6-phenylpyrazineacetate, the product obtained is α-methyl-6-phenylpyrazineacetic acid. Using the procedure of Example XI and replacing ethyl α-methyl-5 -phenylpyrazineacetate with an equivalent amount of ethyl α-methyl-6-phenylpyrazineacetate, the product obtained is α-methyl-6-phenylpyrazineacetamide.

後処理

  1. customat 180° C
  2. customthe product obtained
  3. customthe product obtained
  4. customthe product obtained
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  6. customthe product obtained

出典と根拠

ORDレコード
ord-c596032506e84caf8b313540b0e2a135
出典データセット
uspto-grants-1977_09
特許番号
US04046763

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