Hydrochloric Acid → HCID 18594801、化合物

HRID 2071344ノート

反応式

HRID 2071344 の反応式
[N:1]([CH:4]([CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:5][CH2:6][C@@H:7]1[C@@H:11]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O:20]CC)=[O:19])[C:10](=[O:23])[CH2:9][CH2:8]1)=[N+:2]=[N-:3].CO.O.[OH-].[K+].Cl>CCOCC>[N:1]([CH:4]([CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:5][CH2:6][C@@H:7]1[C@@H:11]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19])[C:10](=[O:23])[CH2:9][CH2:8]1)=[N+:2]=[N-:3]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 18594802HCID 18594802、化合物HCID 22242641Methanol--water (1/1)

生成物 1

HCID 18594801HCID 18594801、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A suspension of 880 mg. of ethyl 15-azido-9-oxo-prostanoate (Example 110) in 15 ml. of methanol-water (1:1) containing 360 mg. of potassium hydroxide is stirred at ambient temperature for 18 hours. The resulting solution is acidified with dilute hydrochloric acid and the oily layer is taken up in ether. The ether is washed with saturated sodi sodium chloride solution, dried with anhydrous magnesium sulfate and taken to dryness to give 797 mg. (98%) of an oil;

後処理

  1. additionA suspension of 880 mg
  2. washThe ether is washed with saturated sodi sodium chloride solution
  3. dry with materialdried with anhydrous magnesium sulfate
  4. customto give 797 mg

出典と根拠

ORDレコード
ord-be2bdaa051cc45858b2e5355ee99d4b3
出典データセット
uspto-grants-1977_09
特許番号
US04046787

反応ノート

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