Hydrochloric Acid → HCID 70637301、化合物

HRID 2071346ノート

反応式

HRID 2071346 の反応式
[NH2:1][CH:2]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:3][CH2:4][C@@H:5]1[C@@H:9]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([O:18]CC)=[O:17])[C:8](=[O:21])[CH2:7][CH2:6]1.[OH-].[K+].[ClH:29].[Cl-].[Na+]>CO.O>[ClH:29].[NH2:1][CH:2]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:3][CH2:4][C@@H:5]1[C@@H:9]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])[C:8](=[O:21])[CH2:7][CH2:6]1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 14797Potassium HydroxideHCID 18594875HCID 18594875、化合物

生成物 1

HCID 70637301HCID 70637301、化合物

試薬・触媒・溶媒 1

HCID 22242641Methanol--water (1/1)溶媒

実験手順

A solution of 1 g. of ethyl 15-amino-9-oxo-prostanoate (Example 143) in 15 ml. of methanol-water (1:1) containing 445 mg. of potassium hydroxide is stirred at ambient temperature for 18 hours. The solution is acidified with hydrochloric acid, saturated with sodium chloride, and extracted several times with methylene chloride. The organic phase is dried with anhydrous magnesium sulfate and taken to dryness to give a viscous oil; λ max. 2.80 - 3.70 (broad), 5.75, and 5.87 μ.

後処理

  1. extractionextracted several times with methylene chloride
  2. dry with materialThe organic phase is dried with anhydrous magnesium sulfate
  3. customto give a viscous oil

出典と根拠

ORDレコード
ord-25f7f657e99748b78a6ef3bb48858ebe
出典データセット
uspto-grants-1977_09
特許番号
US04046787

反応ノート

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