1-(3-Acetylthiopropanoyl)-L-proline → 1-(3-Mercapto-1-oxopropyl)-L-proline
反応式
C([S:4][CH2:5][CH2:6][C:7]([N:9]1[CH2:16][CH2:15][CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8])(=O)C>N>[SH:4][CH2:5][CH2:6][C:7]([N:9]1[CH2:16][CH2:15][CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8]参加物
3
実験手順
1-(3-Acetylthiopropanoyl)-L-proline (0.8 g.) is dissolved in 5.5 N methanolic ammonia (5 ml.) and the solution kept under argon at room temperature. After 2 hours the solvent is removed in vacuo, the residue is dissolved in water and applied to an ion exchange column on the H+ cycle [Dowex 50 (Analytical grade)] and eluted with water. The fractions that give thiol positive reaction are pooled and concentrated to dryness, yield 0.6 g. This product is crystallized from ethyl acetate-hexane as in Procedure A to obtain 1-(3-mercaptopropanoyl)-L-proline.
後処理
- customkept under argon at room temperature
- customAfter 2 hours the solvent is removed in vacuo
- dissolutionthe residue is dissolved in water
- washeluted with water
- customThe fractions that give
- concentrationconcentrated to dryness, yield 0.6 g
- customThis product is crystallized from ethyl acetate-hexane as in Procedure A
出典と根拠
- ORDレコード
- ord-c9d31e367a594153bf5fdd064fc098f3
- 出典データセット
- uspto-grants-1977_09
- 特許番号
- US04046889
反応ノート
読み込み中…