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Phosphorus oxychloride → 2-Chloro-10-(5-methyl-1-pyrrolin-2-YL)phenoxazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 5-Methyl-2-pyrrolidone | HCID 66055 | — |
| 反応物 | 2-Chlorophenoxazine | HCID 10632580 | — |
| 生成物 | 2-Chloro-10-(5-methyl-1-pyrrolin-2-YL)phenoxazine | HCID 22754262 | — |
反応手順
Reaction of 2-chlorophenoxazine, 5-methyl-2-pyrrolidinone and phosphorus oxychloride according to the procedure of Example 1 provides the free base 2-CHLORO-10-(5-METHYL-1-PYRROLIN-2-YL)-PHENOXAZINE as a distillable oil, b.p. 150°-170° C. at 0.1 mm Hg. Conversion of the free base to the hydrochloride salt affords 2-CHLORO-10-(5-METHYL-1-PYRROLIN-2-YL)PHENOXAZINE HYDROCHLORIDE, m.p. 213.5°-215.5° C., as a crystalline solid in a 34% overall yield by refluxing with benzene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04046891 |
| 出典データセット | uspto-grants-1977_09 |
| ORD ID | ord-485821bdb7d1479da564d73b62c6b25d |
| 出典メモ | uspto-grants-1977_09 |