化工社化工社 化学情報印刷レポート · 研究参考用
9,9-Dimethyl-9,10-dihydroacridine → 9,9-Dimethyl-10-(5-methyl-1-pyrrolin-2-YL)acridan
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 9,9-Dimethyl-9,10-dihydroacridine | HCID 22647 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 5-Methyl-2-pyrrolidone | HCID 66055 | — |
| 生成物 | 9,9-Dimethyl-10-(5-methyl-1-pyrrolin-2-YL)acridan | HCID 3044167 | 11% |
反応手順
Reaction of 9,9-dimethylacridan, 5-methyl-2-pyrrolidinone and phosphorus oxychloride according to the procedure of Example 1 provides the free base 9,9-DIMETHYL-10-(5-METHYL-1-PYRROLIN-2-YL)ACRIDAN as a distillable oil, b.p. 160°-180° C. at 0.15 mm Hg. in 11% yield. Conversion of the free base to the hydrochloride salt affords 9,9-DIMETHYL-10-(5-METHYL-1-PYRROLIN-2-YL)ACRIDAN HYDROCHLORIDE, m.p. 232.5°-234.5° C. (dec.) (corr.), by trituration with hot benzene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04046891 |
| 出典データセット | uspto-grants-1977_09 |
| ORD ID | ord-93c9315e970242c78422f417f6e050ba |
| 出典メモ | uspto-grants-1977_09 |