Diazomethane → Methyl 2-ethyl-thiazole-5-carboxylate
反応式
[N+](=[CH2:3])=[N-].[CH2:4]([C:6]1[S:7][C:8]([C:11]([OH:13])=[O:12])=[CH:9][N:10]=1)[CH3:5]>C(Cl)Cl>[CH2:4]([C:6]1[S:7][C:8]([C:11]([O:13][CH3:3])=[O:12])=[CH:9][N:10]=1)[CH3:5]参加物
4
実験手順
A solution of diazomethane in methylene chloride was added to a suspension of 10.45 g of 2-ethyl-thiazole-5-carboxylic acid in 30 ml of methylene chloride until efferversence stopped and the methylene chloride was distilled. The oily residue was chromatographed over silica and was eluted with a 1:1 mixture of benzene-ethyl acetate to obtain 11.3 g of methyl 2-ethyl-thiazole-5-carboxylate.
後処理
- distillationthe methylene chloride was distilled
- customThe oily residue was chromatographed over silica
- washwas eluted with a 1:1 mixture of benzene-ethyl acetate
出典と根拠
- ORDレコード
- ord-eb51efeb4aee4a3ea3665b059cc5fdc1
- 出典データセット
- uspto-grants-1977_09
- 特許番号
- US04046902
反応ノート
読み込み中…