Hydrochloric Acid → Benzoic acid, 2-amino-4-ethyl-, ethyl ester

反応式

[CH2:1]([C:3]1[CH:4]=[C:5]([NH2:12])[C:6](=[CH:10][CH:11]=1)[C:7]([OH:9])=[O:8])[CH3:2].Cl.[CH2:14](O)[CH3:15]>>[NH2:12][C:5]1[CH:4]=[C:3]([CH2:1][CH3:2])[CH:11]=[CH:10][C:6]=1[C:7]([O:9][CH2:14][CH3:15])=[O:8]

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 138270842-Amino-4-ethylbenzoic acid

生成物 1

HCID 21413817Benzoic acid, 2-amino-4-ethyl-, ethyl ester

実験手順

A mixture of 59.4 gm. of 4-ethylanthranilic acid and 1,000 cc. of ethanol is saturated with dry hydrogen chloride gas and then refluxed overnight. The reaction mixture is then concentrated in vacuo and the residue taken up between ether and sodium bicarbonate solution. The ether extract is dried and concentrated in vacuo to give ethyl 2-amino-4-ethylbenzoate as an oil (characterized by IR and NMR).