3-Methyl-5,6,7,8-tetrahydroquinolin-8-ol → 3-Methyl-6,7-dihydroquinolin-8(5H)-one
反応式
[OH:1][CH:2]1[C:11]2[N:10]=[CH:9][C:8]([CH3:12])=[CH:7][C:6]=2[CH2:5][CH2:4][CH2:3]1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:12][C:8]1[CH:9]=[N:10][C:11]2[C:2](=[O:1])[CH2:3][CH2:4][CH2:5][C:6]=2[CH:7]=1参加物
4
実験手順
8-Hydroxy-3-methyl-5,6,7,8-tetrahydroquinoline (42.5g) in methylene chloride (21/21) was stirred at room temperature with manganese dioxide (425g) for 16 hours. The manganese dioxide was removed by filtration and washed with methylene chloride. The filtrate was evaporated to dryness under reduced pressure and the residue was distilled to give 5,6-dihydro-3-methyl-7H-quinolin-8-one (30g) b.p. 142°-4° C. at 0.5mm.
後処理
- customThe manganese dioxide was removed by filtration
- washwashed with methylene chloride
- customThe filtrate was evaporated to dryness under reduced pressure
- distillationthe residue was distilled
出典と根拠
- ORDレコード
- ord-ee5b4520329b4703bb0482176f1da996
- 出典データセット
- uspto-grants-1977_09
- 特許番号
- US04048175
反応ノート
読み込み中…