Methylamine → HCID 70625931、化合物

HRID 2071641ノート

反応式

HRID 2071641 の反応式
[Cl:1][C:2]1[C:3]2[C:4](=[N:14][N:15]([CH3:17])[CH:16]=2)[N:5]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=1.[CH3:18][NH2:19]>>[ClH:1].[CH3:18][NH:19][C:2]1[C:3]2[C:4](=[N:14][N:15]([CH3:17])[CH:16]=2)[N:5]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=1.[CH3:18][N:14]1[C:4]2=[N:5][C:6]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)=[CH:7][CH:2]=[C:3]2[CH2:16][N:15]1[CH3:17]

参加物

4

反応物 2

HCID 6329MethylamineHCID 22756855HCID 22756855、化合物

生成物 2

HCID 70625931HCID 70625931、化合物HCID 131710884HCID 131710884、化合物

実験手順

17 g. of 4-chloro-2-methyl-6-phenyl-2H-pyrazolo[3,4-b]pyridine (0.07 mol.) and 60 ml. of alcoholic methylamine (270 g/l) are heated at 150°-160° in an autoclave for four hours. After cooling to room temperature, the solution is evaporated in vacuo and the residue is extracted with chloroform. To the chloroform extract is added ethereal hydrochloric acid to give the crude hydrochloride of N,2-dimethyl-6-phenyl-2H-pyrazolo[3,4-b]pyridine which, after treatment with ether, becomes crystalline.

後処理

  1. customthe solution is evaporated in vacuo
  2. extractionthe residue is extracted with chloroform
  3. extractionTo the chloroform extract
  4. additionis added ethereal hydrochloric acid

出典と根拠

ORDレコード
ord-9eb8b0dd18c24d4cb5beafbeb06afd0f
出典データセット
uspto-grants-1977_09
特許番号
US04048184

反応ノート

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