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Water → 5-(3-phthalimidopropyl)-5H-dibenzo[a,d]cycloheptene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 5-(3-iodopropyl)-5H-dibenzo[a,d]cycloheptene | HCID 23328868 | — |
| 反応物 | Phthalimide potassium salt | HCID 24194345 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 5-(3-phthalimidopropyl)-5H-dibenzo[a,d]cycloheptene | HCID 21412112 | — |
反応手順
5-(3-Iodopropyl)-5H-dibenzo[a,d]cycloheptene, 1.8 g. (0.005 mole), is dissolved in 10 ml. of dimethylformamide. The solution is stirred while 930 mg. (0.0051 mole) of potassium phthalimide is added. When the addition is complete, the mixture is heated to 85°-90° C. for 40 minutes, then cooled, diluted with chloroform and poured into water. The chloroform layer is separated and the aqueous layer extracted further with chloroform. Evaporation of the chloroform gives the product as an oily crystalline solid. Several recrystallizations from isopropyl alcohol gave product, m.p. 125.5°-131.5° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04048223 |
| 出典データセット | uspto-grants-1977_09 |
| ORD ID | ord-3b5ba246c5794fba8c53474ff6c17a16 |
| 出典メモ | uspto-grants-1977_09 |