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4,6-Dimethoxypyrimidine-5-carbaldehyde → 2,6-Diamino-4-(4,6-dimethoxypyrimid-5-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4,6-Dimethoxypyrimidine-5-carbaldehyde | HCID 4436645 | — |
| 反応物 | Carbamimidoyl-acetic acid ethyl ester | HCID 4599837 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2,6-Diamino-4-(4,6-dimethoxypyrimid-5-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester | HCID 70631685 | 56% |
反応手順
Upon heating a solution of 8.4 g 4,6-dimethoxypyrimidine-5-aldehyde and 13.0 g amidinoacetic acid ethyl ester in 150 ml ethanol for 2 hours, 2,6-diamino-4-(4,6-dimethoxypyrimid-5-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester of m.p. 219° C. (ethanol) is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04049662 |
| 出典データセット | uspto-grants-1977_09 |
| ORD ID | ord-84c4d1be26fa4df0a5d3cb03168ce90e |
| 出典メモ | uspto-grants-1977_09 |