Sulfuric Acid → Propanamide, 2-(dimethylamino)-2-methyl-

HRID 2072002ノート

反応式

HRID 2072002 の反応式
S(=O)(=O)(O)O.[CH3:6][N:7]([CH3:13])[C:8]([CH3:12])([CH3:11])[C:9]#[N:10].[OH-:14].[Ba+2].[OH-]>>[CH3:6][N:7]([CH3:13])[C:8]([CH3:12])([CH3:11])[C:9]([NH2:10])=[O:14]

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 6093286Barium hydroxideHCID 105108312-(Dimethylamino)-2-methylpropanenitrile

生成物 1

HCID 21409863Propanamide, 2-(dimethylamino)-2-methyl-収率 45%

反応条件

温度
90 °C

実験手順

Conc. Sulphuric acid (8 ml.) was added to 2-dimethylamino-2-methyl-propionitrile (2 g.), and was heated to 90° C. and allowed to stand for five mins. The reaction mixture was added to ice cold water (100 ml.), barium hydroxide (32 g.) was added to neutralise the acid and the mixture was filtered (hyflo). The filtrate was evaporated under reduced pressure to give a solid residue which was crystallised from light petroleum (80°-100° C.) to give 2-dimethylamino-2-methylpropionamide (1 g. 45%) m.p. 109°-111° C.

後処理

  1. additionwas added
  2. filtrationthe mixture was filtered (hyflo)
  3. customThe filtrate was evaporated under reduced pressure
  4. customto give a solid residue which
  5. customwas crystallised from light petroleum (80°-100° C.)

出典と根拠

ORDレコード
ord-2ae96e31a52f484991824370ab38fc5a
出典データセット
uspto-grants-1977_09
特許番号
US04049663

反応ノート

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