Acetic Anhydride → Acetamide, N-[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]-

HRID 2072153ノート

反応式

HRID 2072153 の反応式
[C@@H:1]1([NH2:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>C1(C)C=CC=CC=1>[C@@H:1]1([NH:11][C:12](=[O:14])[CH3:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 70580741-Aminotetralin, (S)-

生成物 1

HCID 11412833Acetamide, N-[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]-

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

(S)-1,2,3,4-tetrahydro-1-naphthylamine (26.9 g.) is dissolved in 200 ml. of toluene and 36 g. of acetic anhydride is added while the temperature from the reaction exotherm is moderated at 50° C. to 60° C. with an ice-bath. The solution is heated to reflux for 0.5 hr. and then stirred at room temperature overnight. The mixture is then evaporated to dryness and the residue is washed well with ether. On drying, 26.1 g. of the title compound, m.p. 153° C. to 155° C., is obtained.

後処理

  1. customis moderated at 50° C. to 60° C. with an ice-bath
  2. temperatureThe solution is heated
  3. temperatureto reflux for 0.5 hr
  4. customThe mixture is then evaporated to dryness
  5. washthe residue is washed well with ether
  6. customOn drying

出典と根拠

ORDレコード
ord-c54e3b09e0f6464aa4fa14ae972f4d38
出典データセット
uspto-grants-1977_09
特許番号
US04049717

反応ノート

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