1-Isopropylpiperazine → 1-[2-Hydroxy-3-(4-isopropyl-1-piperazinyl)-4-oxo-2-cyclobuten-1-ylidene]-4-isopropyl-piperazinium hydroxide

HRID 2072286ノート

反応式

HRID 2072286 の反応式
[NH:1]([C:8]1[C:9](=[O:20])[C:10](=[N:13][C:14]2[CH:19]=CC=CC=2)[C:11]=1[OH:12])[C:2]1[CH:7]=CC=CC=1.[CH:21]([N:24]1[CH2:29][CH2:28]NCC1)([CH3:23])[CH3:22]>>[OH-:12].[OH:12][C:11]1[C:10](=[N+:13]2[CH2:14][CH2:19][N:24]([CH:21]([CH3:22])[CH3:23])[CH2:29][CH2:28]2)[C:9](=[O:20])[C:8]=1[N:1]1[CH2:2][CH2:7][N:1]([CH:8]([CH3:9])[CH3:11])[CH2:2][CH2:7]1

参加物

3

反応物 2

HCID 780131-IsopropylpiperazineHCID 109783293-Hydroxy-2-(phenylamino)-4-(phenylimino)-2-cyclobuten-1-one

生成物 1

HCID 214077881-[2-Hydroxy-3-(4-isopropyl-1-piperazinyl)-4-oxo-2-cyclobuten-1-ylidene]-4-isopropyl-piperazinium hydroxide

実験手順

A mixture of 4.0 grams of 2-anilino-3-hydroxy-4-(phenylimino)-2-cyclobuten-1-one and 3.9 grams of 1-isopropylpiperazine is heated at 200°-206° C. in an atmosphere of dry nitrogen for 30 minutes. The mixture is cooled and the resulting solid is comminuted, washed with anhydrous ethyl ether, dried and then recrystallized from water to give 1-[2-hydroxy-3-(4-isopropyl-1-piperazinyl)-4-oxo-2-cyclobuten-1-ylidene]-4-isopropyl-piperazinium hydroxide inner salt melting at about 194.5°-196.5° C.

後処理

  1. temperatureis heated at 200°-206° C. in an atmosphere of dry nitrogen for 30 minutes
  2. temperatureThe mixture is cooled
  3. customthe resulting solid is comminuted
  4. washwashed with anhydrous ethyl ether
  5. customdried
  6. customrecrystallized from water

出典と根拠

ORDレコード
ord-c6989ee03f27499196d869232cfe657b
出典データセット
uspto-grants-1977_09
特許番号
US04051136

反応ノート

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