1,2,3,4-Tetrahydro-1-naphthylamine → 1-Benzoyl-3-(1,2,3,4-tetrahydro-1-naphthyl)urea

HRID 2072368ノート

反応式

HRID 2072368 の反応式
[CH:1]1([NH2:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[C:12]([N:20]=[C:21]=[O:22])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>CCOCC>[C:12]([NH:20][C:21]([NH:11][CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1)=[O:22])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

4

反応物 2

HCID 180661,2,3,4-Tetrahydro-1-naphthylamineHCID 78210Benzoyl isocyanate

生成物 1

HCID 205373051-Benzoyl-3-(1,2,3,4-tetrahydro-1-naphthyl)urea収率 78.6%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

A mixture of 1,2,3,4-tetrahydro-1-naphthylamine (10.01 g) and ether (100 ml) is stirred under a nitrogen atmosphere and a solution of benzoyl isocyanate (9.99 g) in ether (90 ml) is added dropwise. After the addition is completed, the mixture is stirred for 0.5 hour and cooled in ice. The product is collected and washed with cold ether (50 ml) to afford 15.7 g of the title compound, m.p. 166° to 169° C. Recrystallization from acetone affords 13.61 g, m.p. 171° to 173° C.

後処理

  1. additionAfter the addition
  2. stirringthe mixture is stirred for 0.5 hour
  3. temperaturecooled in ice
  4. customThe product is collected
  5. washwashed with cold ether (50 ml)

出典と根拠

ORDレコード
ord-9056e843da3b40b6b9fc88851b80746c
出典データセット
uspto-grants-1977_09
特許番号
US04051183

反応ノート

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