Formamide → 8-[(3,4-Dihydro-2-naphthalenyl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

HRID 2072472ノート

反応式

HRID 2072472 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C:2]=1[CH2:11][N:12]1[CH2:20][CH2:19][C:15]([NH:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)([C:16]([NH2:18])=[O:17])[CH2:14][CH2:13]1.[CH:28](N)=O.C(OCC)(=O)C>O>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C:2]=1[CH2:11][N:12]1[CH2:20][CH2:19][C:15]2([N:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:28][NH:18][C:16]2=[O:17])[CH2:14][CH2:13]1

参加物

5

反応物 3

HCID 713FormamideHCID 8857Ethyl AcetateHCID 214082231-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotamide

生成物 1

HCID 214082128-[(3,4-Dihydro-2-naphthalenyl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
170 °C

実験手順

A mixture of 1-[(3,4-dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotamide (5.0 g) and formamide (18 g) is heated for 12 hours at 170° C. The reaction mixture is cooled, diluted with water (100 ml), and extracted with chloroform. The chloroform solution is dried over sodium sulfate and concentrated to give crude product. Trituration with ethyl acetate produces the title compound.

後処理

  1. temperatureThe reaction mixture is cooled
  2. extractionextracted with chloroform
  3. dry with materialThe chloroform solution is dried over sodium sulfate
  4. concentrationconcentrated
  5. customto give crude product

出典と根拠

ORDレコード
ord-9d18760453b047a1b98f888caa04b72a
出典データセット
uspto-grants-1977_09
特許番号
US04051248

反応ノート

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