Aniline → 1-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotonitrile

HRID 2072477ノート

反応式

HRID 2072477 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C:2]=1[CH2:11][N:12]1[CH2:17][CH2:16][C:15](=O)[CH2:14][CH2:13]1.[NH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[C-:26]#[N:27].[K+].[OH-].[NH4+]>O.C(O)(=O)C>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C:2]=1[CH2:11][N:12]1[CH2:17][CH2:16][C:15]([NH:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)([C:26]#[N:27])[CH2:14][CH2:13]1

参加物

7

反応物 4

HCID 6115AnilineHCID 9032Potassium CyanideHCID 14923Ammonium HydroxideHCID 214082251-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-oxopiperidine

生成物 1

HCID 537070301-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotonitrile

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒

反応条件

温度
30 °C

実験手順

A mixture of 1-[(3,4-dihydro-2-naphthalenyl)methyl]-4-oxopiperidine (24.0 g), aniline (9.3 g), and glacial acetic acid (70 ml) is cooled to 30° C and heated with a solution of potassium cyanide (7.2 g) in water (20 ml). The resulting mixture is stirred for 16 hours at room temperature. The reaction mixture is poured into aqueous ammonium hydroxide and extracted with chloroform. The organic solution is dried and concentrated to give the title compound.

後処理

  1. extractionextracted with chloroform
  2. customThe organic solution is dried
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-f55c85131ed143b1bd9418451088a7dd
出典データセット
uspto-grants-1977_09
特許番号
US04051248

反応ノート

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