Sulfuric Acid → 1-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotamide

HRID 2072484ノート

反応式

HRID 2072484 の反応式
O[CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][CH:3]1[CH2:12][N:13]1[CH2:20][CH2:19][C:16]([NH:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)([C:17]#[N:18])[CH2:15][CH2:14]1.S(=O)(=O)(O)[OH:29].[OH-].[NH4+]>>[CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][C:3]=1[CH2:12][N:13]1[CH2:14][CH2:15][C:16]([NH:21][C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)([C:17]([NH2:18])=[O:29])[CH2:19][CH2:20]1

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 14923Ammonium HydroxideHCID 543671651-[(1,2,3,4-Tetrahydro-1-hydroxy-2-naphthalenyl)methyl]-4-anilino isonipecotonitrile

生成物 1

HCID 214082231-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotamide

反応条件

温度
70 °C

実験手順

A mixture of 1-[(1,2,3,4-tetrahydro-1-hydroxy-2-naphthalenyl)-methyl]-4-anilino isonipecotonitrile (5.0 g) and 90% sulfuric acid (60.0 g) is heated for 10 minutes at 70° C. The mixture is then stirred at room temperature for an additional hour. The reaction mixture is poured into ice-water, basified with ammonium hydroxide, and extracted with chloroform. Concentration of the dried chloroform solution followed by trituration with benzene yields the title compound.

後処理

  1. extractionextracted with chloroform

出典と根拠

ORDレコード
ord-2ae114cd6fcf489ea27716a49e175767
出典データセット
uspto-grants-1977_09
特許番号
US04051248

反応ノート

読み込み中…