3-Phenylphenol → Methyl(3-phenylphenoxy)acetate

HRID 2072581ノート

反応式

HRID 2072581 の反応式
[C:1]1([C:7]2[CH:8]=[C:9]([OH:13])[CH:10]=[CH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:15][C:16]([O:18][CH3:19])=[O:17].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C.O>[C:1]1([C:7]2[CH:8]=[C:9]([CH:10]=[CH:11][CH:12]=2)[O:13][CH2:15][C:16]([O:18][CH3:19])=[O:17])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

6

反応物 3

HCID 113813-PhenylphenolHCID 11430Potassium CarbonateHCID 60984Methyl bromoacetate

生成物 1

HCID 13787157Methyl(3-phenylphenoxy)acetate

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 3-phenylphenol (5.00 g), methyl bromoacetate (3.1 ml) and potassium carbonate (8.1 g) in DMF was stirred at room temperature. After five hours, the reaction mixture was diluted with water (100 ml) and then extracted with ether. The combined organic layers were washed with aqueous sodium carbonate followed by brine and then dried, filtered and evaporated to give crude methyl (3-phenylphenoxy)acetate (7.2 g) as a pale yellow liquid, 1H NMR (CDCl3) delta 3.8 (3H,s), 4.7 (2H,s), 6.8-7.6 (9H,m) ppm.

後処理

  1. extractionextracted with ether
  2. washThe combined organic layers were washed with aqueous sodium carbonate
  3. customdried
  4. filtrationfiltered
  5. customevaporated

出典と根拠

ORDレコード
ord-305bc901054e41edb770689a8a579347
出典データセット
uspto-grants-1990_04
特許番号
US04913721

反応ノート

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