tert-Butyl (4-chlorobutyl)carbamate → Diethyl 2-(4-((tert-butoxycarbonyl)amino)butyl)malonate

HRID 2072820ノート

反応式

HRID 2072820 の反応式
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12]Cl)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:14]([O:17][CH2:18][CH3:19])(=[O:16])[CH3:15].[OH2:20]>>[CH2:18]([O:17][C:14](=[O:16])[CH:15]([C:6]([O:5][CH2:1][CH3:2])=[O:20])[CH2:12][CH2:11][CH2:10][CH2:9][NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH3:19]

参加物

3

反応物 2

HCID 19758183tert-Butyl (4-chlorobutyl)carbamateHCID 22728543Water ethylacetate

生成物 1

HCID 53641101Diethyl 2-(4-((tert-butoxycarbonyl)amino)butyl)malonate

実験手順

N-[(tert-butoxy)carbonyl]-4-chloro-butylamine (2.5 g, 0.012 mol) is then gradually added to the resulting mixture at room temperature. The reaction mixture is stirred at room temperature for 2 hours and at the reflux temperature for 6 hours, and then poured into ethyl acetate/water (1/1, v/v) (100 ml). The organic phase is separated, washed several times with water, and dried over MgSO4.

後処理

  1. customThe organic phase is separated
  2. washwashed several times with water
  3. dry with materialdried over MgSO4

出典と根拠

ORDレコード
ord-0b0cc111c0634abcb66deed5e4ca8dc8
出典データセット
uspto-grants-1990_04
特許番号
US04914226

反応ノート

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