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3'-Fluoro-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid → 4-(3-Fluoro-4-hydroxyphenyl)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3'-Fluoro-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid | HCID 1203166 | — |
| 溶媒 | Hydrogen Bromide | HCID 260 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 4-(3-Fluoro-4-hydroxyphenyl)benzoic acid | HCID 836139 | 95.1% |
反応手順
Subsequently, 6.8 g of 3'-fluoro-4'-methoxybiphenyl-4-carboxylic acid was heated under reflux for 14 hours in 150 ml of 48% hydrobromic acid and 80 ml of dioxane. The volatile components were removed by evaporator, and the residue was washed several times with water to give 6.10 g (yield 95%) of the desired 3'-fluoro-4'-hydroxybiphenyl-4-carboxylic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04914224 |
| 出典データセット | uspto-grants-1990_04 |
| ORD ID | ord-ec7130a167cd40439ec21d6be6c0ee8b |
| 出典メモ | uspto-grants-1990_04 |