Ammonium Hydroxide → 7-Phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide

HRID 2073184

反応式

HRID 2073184 の反応式
[C:1]1([C:7]2[N:12]3[N:13]=[CH:14][C:15]([C:16]#[N:17])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-:18].[NH4+]>S(=O)(=O)(O)O>[C:1]1([C:7]2[N:12]3[N:13]=[CH:14][C:15]([C:16]([NH2:17])=[O:18])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 14923Ammonium HydroxideHCID 14804157-Phenylpyrazolo[1,5-a]pyrimidine-3-carbonitrile

生成物 1

HCID 145018607-Phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

A mixture of 4.0 g of 7-phenylpyrazolo[1,5-a]pyrimidine-3-carbonitrile (prepared as described in Example 7 of U.S. Pat. No. 4,236,005) and 40 ml of concentrated sulfuric acid was stirred at room temperature for 16 hours. The solution was then carefully poured into ice with stirring and the mixture was carefully made just basic with concentrated ammonium hydroxide. The solid was collected by filtration and recrystallized from dichloromethane to give pale yellow needles m.p. 236°-238.5° C.

後処理

  1. customprepared
  2. additionThe solution was then carefully poured into ice
  3. filtrationThe solid was collected by filtration
  4. customrecrystallized from dichloromethane

出典と根拠

ORDレコード
ord-6ce34974c9db43c5961da614671bb131
出典データセット
uspto-grants-1990_04
特許番号
US04916137

関連ノート

読み込み中…