Diethyl Ether → 3-Bromo-1,1-bis(4-fluorophenyl)propane

HRID 2073481ノート

反応式

HRID 2073481 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[CH2:9][CH2:10]O)=[CH:4][CH:3]=1.P(Br)(Br)[Br:20].CCOCC>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[CH2:9][CH2:10][Br:20])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 24614Phosphorus tribromideHCID 197832883,3-Bis(4-fluorophenyl)propanol

生成物 1

HCID 138832773-Bromo-1,1-bis(4-fluorophenyl)propane

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

反応条件

温度
60 °C

実験手順

50.1 g (0.202 mol) of 3,3-bis(4-fluorophenyl)propanol were dissolved in 150 ml of toluene, and a solution of 21.8 g (0.081 mol) of PBr3 in 50 ml of toluene was added dropwise. The mixture was stirred at room temperature for 30 minutes and at 60° C. for 90 minutes and, for hydrolysis, was poured onto 400 ml of ice, 200 ml of ether were added, the organic phase was separated off, washed with NaHCO3 solution and NaCl solution, dried and concentrated and the residue was distilled in vacuo for purification.

後処理

  1. additionwere added
  2. customthe organic phase was separated off
  3. washwashed with NaHCO3 solution and NaCl solution
  4. customdried
  5. concentrationconcentrated
  6. distillationthe residue was distilled in vacuo for purification

出典と根拠

ORDレコード
ord-e191d02e21a043de9c13d75fe7081c88
出典データセット
uspto-grants-1990_04
特許番号
US04918073

反応ノート

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