Sulfuric Acid → 4'-Chloro-2-hydroxymethylbenzhydrol

HRID 2073502ノート

反応式

HRID 2073502 の反応式
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=2[C:10](O)=[O:11])=[O:7])=[CH:4][CH:3]=1.S(=O)(=O)(O)O>CO>[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([CH:6]([C:8]2[C:9]([CH2:10][OH:11])=[CH:13][CH:14]=[CH:15][CH:16]=2)[OH:7])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 1118Sulfuric AcidHCID 665642-(4'-Chlorobenzoyl)benzoic acid

生成物 1

HCID 197815594'-Chloro-2-hydroxymethylbenzhydrol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 55 g (0.3M) of 2-(4-chlorobenzoyl) benzoic acid, 5 ml of concentrated sulphuric acid and 500 ml of methanol was heated under reflux for 3 hours. The mixture was evaporated and the residue was taken up in dichloromethane washed with water then aqueous sodium bicarbonate. The dichloromethane was dried and evaporated. The residue was then reduced with lithium aluminium hydride in an analogous manner to that described in Example X1 to give the title compound.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hours
  3. customThe mixture was evaporated
  4. washwashed with water
  5. dry with materialThe dichloromethane was dried
  6. customevaporated

出典と根拠

ORDレコード
ord-c8d69d0943f44b218e9d062dc84daf2c
出典データセット
uspto-grants-1990_04
特許番号
US04918083

反応ノート

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