Bromine → HCID 19857641、化合物
反応式
[Br:1]Br.Cl.[CH:4]([C:7]1[CH:13]=[CH:12][CH:11]=[C:10]([CH:14]([CH3:16])[CH3:15])[C:8]=1[NH2:9])([CH3:6])[CH3:5]>ClCCCl>[BrH:1].[Br:1][C:12]1[CH:13]=[C:7]([CH:4]([CH3:6])[CH3:5])[C:8]([NH2:9])=[C:10]([CH:14]([CH3:16])[CH3:15])[CH:11]=1参加物
4
反応条件
- 温度
- 0 °C
実験手順
19.1 g of bromine are added dropwise at 0° C. over 1 hour to a suspension of 24.1 g of 2,6-diisopropylaniline hydrochloride in 250 ml of 1,2-dichloroethane. The reaction mixture is stirred for 1 hour at 0° C. and then filtered. The filter residue is washed with 1,2-dichloroethane and then dried at 40° C. under vacuum, affording 36.8 g (97% of theory) of 4-bromo-2,6-diisopropylaniline hydrobromide in the form of yellow crystals which melt at 235°-237° C. after recrystallisation from ethyl acetate.
後処理
- filtrationfiltered
- washThe filter residue is washed with 1,2-dichloroethane
- customdried at 40° C. under vacuum
出典と根拠
- ORDレコード
- ord-6b020719a53f41429aafdc9642d38bd2
- 出典データセット
- uspto-grants-1990_04
- 特許番号
- US04918230
反応ノート
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