Ammonia → 5-Amino-1-(4-methoxyphenyl)-1H-pyrazole-4-carboxamide

反応式

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:13]([NH2:14])=[C:12]([C:15]#[N:16])[CH:11]=[N:10]2)=[CH:5][CH:4]=1.N.S(=O)(=O)(O)[OH:19]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[C:13]([NH2:14])=[C:12]([C:15]([NH2:16])=[O:19])[CH:11]=[N:10]2)=[CH:7][CH:8]=1

参加物

反応物 3

HCID 222Ammonia

HCID 1118Sulfuric Acid

HCID 27638735-amino-1-(4-methoxyphenyl)-1H-pyrazole-4-carbonitrile

生成物 1

HCID 198559845-Amino-1-(4-methoxyphenyl)-1H-pyrazole-4-carboxamide

実験手順

1.5 g of 1-(4-methoxyphenyl)-5-amino-4-pyrazolecarbonitrile were stirred at 10°-15° C. with 10 ml of concentrated sulphuric acid until all of the solid had dissolved. The mixture was poured on to 60 g of crushed ice and made basic with concentrated ammonia solution. The precipitated product was filtered off, washed with water and recrystallized from ethanol to give 900 mg of 1-(4-methoxyphenyl)-5-amino-4-pyrazolecarboxamide of melting point 213°-215° C.