Ethanol → HCID 178487786、化合物

関与物質

反応条件

反応手順

To a stirred suspension of 14.7 g 2-chloro-6-methoxy-3-quinolinecarbonitrile in 465 ml absolute ethanol was added 17 ml of hydrazine hydrate. The mixture was stirred at reflux for 24 hours and then cooled to 0° C. The resulting solid product was collected by filtration and boiled with 200 ml water to remove any hydrazine dihydrochloride present. The resulting material was filtered and dried in vacuo (90° C.), and recrystallized from 300 ml dimethylformamide to give 12.3 g 6-methoxy-1H-pyrazolo[3,4-b]quinolin-3-amine as a bright-yellow solid, m.p. >300° C.

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