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Water → 2-Amino-3-(2-methyl-6-methoxycarbonylaminobenzylamino)pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | 2-Amino-3-(2-methyl-6-methoxycarbonylaminobenzylideneamino)pyridine | HCID 14499824 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 2-Amino-3-(2-methyl-6-methoxycarbonylaminobenzylamino)pyridine | HCID 14499817 | 94.1% |
反応手順
To a solution of 2-amino-3-(2-methyl-6-methoxycarbonylaminobenzylideneamino)pyridine (229 mg) in methanol (4.6 ml) and chloroform (4.6 ml) was added sodium borohydride (200 mg) and the mixture was stirred for 3.5 hours at room temperature. After water was added, organic layer was separated and dried over magnesium chloride. The solvent was evaporated under reduced pressure. The residue was triturated with diethyl ether to give 2-amino-3-(2-methyl-6-methoxycarbonylaminobenzylamino)pyridine (217 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04920129 |
| 出典データセット | uspto-grants-1990_04 |
| ORD ID | ord-7b8224e273b24a24b6518a7792f389bf |
| 出典メモ | uspto-grants-1990_04 |