Potassium Carbonate → Ethyl 2-(3-(2-(3-(2-quinolinylmethyloxy)phenyl)-2-oxoethyl)phenoxy)acetate

HRID 2073906ノート

反応式

HRID 2073906 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([C:8](=[O:23])[CH2:9][C:10]2[CH:11]=[C:12]([CH:20]=[CH:21][CH:22]=2)[O:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:5]=[CH:6][CH:7]=1.Cl[CH2:25][C:26]1[CH:35]=[CH:34][C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[N:27]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[N:27]1[C:28]2[C:33](=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:34]=[CH:35][C:26]=1[CH2:25][O:1][C:2]1[CH:3]=[C:4]([C:8](=[O:23])[CH2:9][C:10]2[CH:11]=[C:12]([CH:20]=[CH:21][CH:22]=2)[O:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 203942-(Chloromethyl)quinolineHCID 14774136Ethyl 2-(3-(2-(3-hydroxyphenyl)2-oxoethyl)phenoxy)acetate

生成物 1

HCID 14774137Ethyl 2-(3-(2-(3-(2-quinolinylmethyloxy)phenyl)-2-oxoethyl)phenoxy)acetate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

A mixture of ethyl 2-(3-(2-(3-hydroxyphenyl)2-oxoethyl)phenoxy)acetate (0.01 mol), 2-chloromethylquinoline (0.01 mol), and K2CO3 (0.01 mol) in 20 mL of DMF are heated at 60° C. overnight. After work-up, the crude product is purified by flash chromatography to give ethyl 2-(3-(2-(3-(2-quinolinylmethyloxy)phenyl)-2-oxoethyl)phenoxy)acetate.

後処理

  1. customAfter work-up, the crude product is purified by flash chromatography

出典と根拠

ORDレコード
ord-2c3d24bea6614688b35a67f6b5913618
出典データセット
uspto-grants-1990_04
特許番号
US04920131

反応ノート

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