1-Acetyl-5-carbomethoxy-7-chloro-4-methoxy-1,2-dihydroindole → 1-Acetyl-5-carboxy-7-chloro-4-methoxy-1,2-dihydroindole

HRID 2074003ノート

反応式

HRID 2074003 の反応式
[C:1]([N:4]1[C:12]2[C:7](=[C:8]([O:18][CH3:19])[C:9]([C:14]([O:16]C)=[O:15])=[CH:10][C:11]=2[Cl:13])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]>[OH-].[Na+].CO>[C:1]([N:4]1[C:12]2[C:7](=[C:8]([O:18][CH3:19])[C:9]([C:14]([OH:16])=[O:15])=[CH:10][C:11]=2[Cl:13])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

参加物

3

反応物 1

HCID 105649501-Acetyl-5-carbomethoxy-7-chloro-4-methoxy-1,2-dihydroindole

生成物 1

HCID 148832261-Acetyl-5-carboxy-7-chloro-4-methoxy-1,2-dihydroindole

試薬・触媒・溶媒 1

HCID 23721981Sodium hydroxide methanol溶媒

実験手順

A mixture of the indole ester of step 9 above (0.8 g) and 10% aqueous NaOH/MeOH (20 ml/80 ml) is stirred under reflux for 2 hours. The reaction mixture is concentrated and the aqueous residue is diluted with water and extracted with CHCl3. The organic layer is dried (MgSO4) and evaporated affording an off-white solid which is determined to be the desired compound by NMR.

後処理

  1. temperatureunder reflux for 2 hours
  2. concentrationThe reaction mixture is concentrated
  3. additionthe aqueous residue is diluted with water
  4. extractionextracted with CHCl3
  5. dry with materialThe organic layer is dried (MgSO4)
  6. customevaporated
  7. customaffording an off-white solid which

出典と根拠

ORDレコード
ord-2d6adf4bd802410b97733c9b3797b538
出典データセット
uspto-grants-1990_04
特許番号
US04920219

反応ノート

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