化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → 2-(Benzooxazol-2-ylaminomethyl)-piperidine-1-carboxylic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-Chlorobenzoxazole | HCID 11986 | — |
| 反応物 | tert-Butyl 2-(aminomethyl)piperidine-1-carboxylate | HCID 2756482 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-(Benzooxazol-2-ylaminomethyl)-piperidine-1-carboxylic acid tert-butyl ester | HCID 66570237 | 110.9% |
反応手順
(RS) 2-Aminomethyl-piperidine-1-carboxylic acid tert butyl ester (0.21 g) and 2-chlorobenzoxazole (0.153 g) and triethylamine (0.1 g) were combined in tetrahydrofuran (10 ml) and stirred at room temperature for 4 hours. The mixture was partitioned between ethyl acetate and water, the organic phase dried and solvent removed at reduced pressure to give the title compound (0.36 g) as an oil that solidified on standing.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07919507B2 |
| 出典データセット | uspto-grants-2011_04 |
| ORD ID | ord-b2b55cbca7c74a09974c2a810ced2fb4 |
| 出典メモ | uspto-grants-2011_04 |