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Dimethylformamide → 7-(4-bromobutoxy)-8-propyl-4-(trifluoromethyl)-2H-chromen-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 1,4-Dibromobutane | HCID 8056 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Trifluoromethyl-8-propyl-7-hydroxycoumarin | HCID 53701430 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 7-(4-bromobutoxy)-8-propyl-4-(trifluoromethyl)-2H-chromen-2-one | HCID 57963014 | 105.4% |
反応手順
An N,N-dimethylformamide (5 mL) solution of 7-hydroxy-8-propyl-4-(trifluoromethyl)-2H-chromen-2-one (500 mg, 1.84 mmol), 1,4-dibromobutane (2.19 mL, 18.36 mmol), and potassium carbonate (375 mg, 2.76 mmol) was stirred overnight at room temperature. The reaction solution was added with water and extracted with ethyl acetate. Subsequently, the organic layer was washed with saturated saline, dried using anhydrous sodium sulfate, and concentrated under vacuum. The obtained residue was purified using silica-gel chromatography (hexane:ethyl acetate=10:1), and the title compound (0.79 g) was obtained as yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07919509B2 |
| 出典データセット | uspto-grants-2011_04 |
| ORD ID | ord-57a940b758594132aef2836b23d3e696 |
| 出典メモ | uspto-grants-2011_04 |