Hydrochloric Acid → 2-[3,5-Bis(trifluoromethyl)phenyl]-n{4-(5-fluoro-2-methylphenyl)-6-[(7s,9as)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1h)-yl]-3-pyridinyl}-n,2-dimethylpropanamide hydrochloride

HRID 2074918ノート

反応式

HRID 2074918 の反応式
[ClH:1].[F:2][C:3]([F:48])([F:47])[C:4]1[CH:5]=[C:6]([C:14]([CH3:46])([CH3:45])[C:15]([N:17]([C:19]2[CH:20]=[N:21][C:22]([N:33]3[C@H:42]([CH2:43][OH:44])[CH2:41][N:40]4[C@H:35]([CH2:36][O:37][CH2:38][CH2:39]4)[CH2:34]3)=[CH:23][C:24]=2[C:25]2[CH:30]=[C:29]([F:31])[CH:28]=[CH:27][C:26]=2[CH3:32])[CH3:18])=[O:16])[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1>>[ClH:1].[F:12][C:10]([F:11])([F:13])[C:8]1[CH:7]=[C:6]([C:14]([CH3:46])([CH3:45])[C:15]([N:17]([C:19]2[CH:20]=[N:21][C:22]([N:33]3[C@H:42]([CH2:43][OH:44])[CH2:41][N:40]4[C@H:35]([CH2:36][O:37][CH2:38][CH2:39]4)[CH2:34]3)=[CH:23][C:24]=2[C:25]2[CH:30]=[C:29]([F:31])[CH:28]=[CH:27][C:26]=2[CH3:32])[CH3:18])=[O:16])[CH:5]=[C:4]([C:3]([F:2])([F:48])[F:47])[CH:9]=1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 160639132-[3,5-Bis(trifluoromethyl)phenyl]-n{4-(5-fluoro-2-methylphenyl)-6-[(7s,9as)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1h)-yl]-3-pyridinyl}-n,2-dimethylpropanamide

生成物 1

HCID 160639482-[3,5-Bis(trifluoromethyl)phenyl]-n{4-(5-fluoro-2-methylphenyl)-6-[(7s,9as)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1h)-yl]-3-pyridinyl}-n,2-dimethylpropanamide hydrochloride

実験手順

HCl salt made according to method described in Example 41 starting from 2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(5-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide (E45, 11.5 mg) to afford a pale yellow solid

後処理

  1. customto afford a pale yellow solid

出典と根拠

ORDレコード
ord-4d3f45f997624c1fbf1eeccbed118645
出典データセット
uspto-grants-2011_04
特許番号
US07919491B2

反応ノート

読み込み中…