Ammonium Hydroxide → HCID 67089595、化合物
反応式
[F:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([C:12]([NH:14][NH:15][C:16]([NH2:18])=[S:17])=O)=[CH:7][CH:6]=2.[OH-].[NH4+]>S(=O)(=O)(O)O>[F:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([C:12]1[S:17][C:16]([NH2:18])=[N:15][N:14]=1)=[CH:7][CH:6]=2参加物
4
実験手順
A mixture of 1-(3-fluoroisoquinoline-6-carbonyl)thiosemicarbazide (0.98 g, 3.71 mmol) in sulfuric acid (10 mL) was stirred at room temperature for 3 hours. The mixture was poured into ice-ammonium hydroxide (33%). The pH was adjusted to >9 with additional ammonium hydroxide. The precipitate was recovered by filtration and washed with water (4×) to provide the product as an off-white solid (0.84 g, 92%). LCMS (API-ES) m/z: 247 (M+H+).
後処理
- filtrationThe precipitate was recovered by filtration
- washwashed with water (4×)
出典と根拠
- ORDレコード
- ord-9f61a7c4cbd9448e9386f9014152e54e
- 出典データセット
- uspto-grants-2011_04
- 特許番号
- US07919504B2
反応ノート
読み込み中…