4-Chloro-L-phenylalanine → 6-(5-((S)-2-Amino-3-(4-chlorophenyl)propylamino)-1,3,4-thiadiazol-2-yl)benzo[d]oxazol-2(3H)-one

反応式

F[C:2]1[CH:3]=[C:4]([C:11]2[S:15][C:14]([NH:16][C:17](=O)OC(C)(C)C)=[N:13][N:12]=2)[CH:5]=[CH:6][C:7]=1[N+:8]([O-])=O.[Cl:24][C:25]1[CH:45]=[CH:44][C:28]([CH2:29][C@H:30]2[CH2:34][O:33][S:32](=[O:36])(=[O:35])[N:31]2[C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])=[CH:27][CH:26]=1.N[C@@H](CC1C=CC(Cl)=CC=1)[C:48]([OH:50])=[O:49]>>[NH2:31][C@@H:30]([CH2:29][C:28]1[CH:27]=[CH:26][C:25]([Cl:24])=[CH:45][CH:44]=1)[CH2:17][NH:16][C:14]1[S:15][C:11]([C:4]2[CH:5]=[CH:6][C:7]3[NH:8][C:48](=[O:49])[O:50][C:2]=3[CH:3]=2)=[N:12][N:13]=1.[Cl:24][C:25]1[CH:26]=[CH:27][C:28]([CH2:29][C@H:30]2[CH2:34][O:33][S:32](=[O:36])(=[O:35])[N:31]2[C:37]([O:39][C:40]([CH3:41])([CH3:42])[CH3:43])=[O:38])=[CH:44][CH:45]=1