Chloroacetaldehyde → HCID 67091020、化合物
反応式
Cl[CH2:2][CH:3]=O.C(=O)(O)[O-].[Na+].[I:10][C:11]1[CH:12]=[C:13]2[C:18](=[CH:19][CH:20]=1)[N:17]=[C:16]([NH2:21])[CH:15]=[CH:14]2>O1CCOCC1>[I:10][C:11]1[CH:12]=[C:13]2[C:18](=[CH:19][CH:20]=1)[N:17]1[CH:2]=[CH:3][N:21]=[C:16]1[CH:15]=[CH:14]2参加物
5
反応条件
- 温度
- 80 °C
実験手順
To chloroacetaldehyde (50 wt %, 460 mg, 2.92 mmol) and sodium bicarbonate (613 mg, 7.3 mmol) was added 6-Iodo-quinolin-2-ylamine (390 mg, 1.46 mmol) in 1,4-dioxane (5 mL). The mixture was heated to 80° C. overnight, and then cooled to room temperature. The solvent was removed in vacuo, and the residue was purified by silica gel chromatography (50-100% EtOAc in hexanes) to obtain the desired product, 1g.
後処理
- temperaturecooled to room temperature
- customThe solvent was removed in vacuo
- customthe residue was purified by silica gel chromatography (50-100% EtOAc in hexanes)
出典と根拠
- ORDレコード
- ord-f87b7f1d01ba4a3dabd91721cd9deb0b
- 出典データセット
- uspto-grants-2011_04
- 特許番号
- US07919621B2
反応ノート
読み込み中…