2-Pyridinecarboxaldehyde → 7-Iodo-1-pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinoline

HRID 2075691ノート

反応式

HRID 2075691 の反応式
[I:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][NH2:13])[CH:6]=[CH:5]2.[N:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH:20]=O.C(O)(=O)C.C(O)(=O)C.IC1C=CC=CC=1>C(Cl)Cl>[I:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[C:20]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][N:14]=3)=[N:13][N:12]=[C:7]1[CH:6]=[CH:5]2

参加物

5

反応物 3

HCID 142732-PyridinecarboxaldehydeHCID 12217721Iodo benzene diacetateHCID 53403040(6-Iodo-quinolin-2-yl)-hydrazine

生成物 1

HCID 670909637-Iodo-1-pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinoline

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To (6-Iodo-quinolin-2-yl)-hydrazine (2.99 g, 10.5 mmol) suspended in CH2Cl2 (30 mL) was added 2-pyridinecarboxaldehyde (1.2 mL, 12.6 mmol). The reaction was stirred at room temperature for 2 hours, followed by the addition of iodobenzene diacetate (3.39 g, 10.5 mmol). The reaction was stirred overnight at room temperature, during which time a precipitate formed. The mixture was concentrated to half the volume, and the precipitate was filtered and washed with minimal CH2Cl2 to give the desired product, 5k. The filtrate was concentrated and suspended in EtOH. After stirring overnight at room temperature, the mixture was filtered and rinsed with EtOH to obtain additional product, 5k.

後処理

  1. stirringThe reaction was stirred overnight at room temperature, during which time a precipitate
  2. customformed
  3. concentrationThe mixture was concentrated to half the volume
  4. filtrationthe precipitate was filtered
  5. washwashed with minimal CH2Cl2

出典と根拠

ORDレコード
ord-0de7e5fe627a46139bccc5c89a4503f6
出典データセット
uspto-grants-2011_04
特許番号
US07919621B2

反応ノート

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